Équipes
INRAE-ENVT, Equipe VIRéMIE, Virus: Emergence, Interactions et Evolution, Toulouse
INRAE-ENVT VIRéMIE
Présentation
L’équipe Virus : Emergences, interactions et évolution (VIRéMIE) de l’UMR INRAe-ENVT 1225 Interactions Hôtes-Agents Pathogènes (IHAP) est une structure de recherche en infectiologie animale, rattachée au département de santé animale de l’INRAe et basée sur le site de l’Ecole Nationale Vétérinaire de Toulouse.
Les principaux objectifs de recherche sont de comprendre les interactions entre les virus et leurs hôtes, aux différentes échelles du vivant (moléculaire, cellulaire, individuel, population). Les finalités des recherches menées par l’équipe sont de contribuer à la maîtrise des viroses infectieuses animales et à la protection de la santé humaine, en particulier dans les domaines des zoonoses. Les recherches s’inscrivent dans le concept « One Health ».
Les recherches de l’équipe s’articulent autour de 3 axes thématiques :
- Evolution, plasticité et émergence des pathogènes,
- Compréhension des mécanismes infectieux et de la réponse de l’hôte,
- Amélioration du contrôle et de la maitrise des maladies infectieuses.
Nos modèles d’étude viraux sont principalement les virus influenza, ainsi que plus généralement les virus respiratoires des volailles et des ruminants, ainsi que les virus émergents.
Publications Récentes
Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus in Poultry, Benin, 2021
Genetic Evolution of Avian Influenza A (H9N2) Viruses Isolated from Domestic Poultry in Uganda Reveals Evidence of Mammalian Host Adaptation, Increased Virulence and Reduced Sensitivity to Baloxavir
Understanding the mechanisms of viral and bacterial coinfections in bovine respiratory disease: a comprehensive literature review of experimental evidence
Avian Influenza a H9N2 Viruses in Morocco, 2018-2019
Development and assessment of a new bioassay for accurate quantification of Type I interferons induced by bovine respiratory viruses
Hydroxychloroquine inhibits proteolytic processing of endogenous TLR7 protein in human primary plasmacytoid dendritic cells.
Influenza A viruses are likely highly prevalent in South African swine farms.
La lutte contre l’émergence des virus influenza aviaires hautement pathogènes : un des défis du XXIe siècle ? [Controlling the emergence of highly pathogenic avian influenza viruses: one of the challenges of the 21st century?]
Influence of viral genome properties on polymerase fidelity
Pathobiology of highly pathogenic H5 avian influenza viruses in naturally infected Galliformes and Anseriformes in France during winter 2015-2016
Opposite Outcomes of the Within- Host Competition between High- and Low-Pathogenic H5N8 Avian Influenza Viruses in Chickens Compared to Ducks.
Influenza vaccination induces autoimmunity against orexinergic neurons in a mouse model for narcolepsy.
Influenza viruses and coronaviruses: Knowns, unknowns, and common research challenges.
Influenza D virus in respiratory disease in Canadian, province of Québec, cattle: Relative importance and evidence of new reassortment between different clades
First expert elicitation of knowledge on drivers of emergence of influenza D in Europe.
Phylodynamic study of the conserved RNA structure encompassing the hemagglutinin cleavage site encoding region of H5 and H7 low pathogenic avian influenza viruses
Enhanced Pathogenesis Caused by Influenza D Virus and Mycoplasma bovis Coinfection in Calves: a Disease Severity Linked with Overexpression of IFN-γ as a Key Player of the Enhanced Innate Immune Response in Lungs
Immunogenicity and Protective Potential of Mucosal Vaccine Formulations Based on Conserved Epitopes of Influenza A Viruses Fused to an Innovative Ring Nanoplatform in Mice and Chickens
Serological Surveillance of Influenza D Virus in Ruminants and Swine in West and East Africa, 2017-2020.
Protective Efficacy Evaluation of Four Inactivated Commercial Vaccines Against Low Pathogenic Avian Influenza H9N2 Virus Under Experimental Conditions in Broiler Chickens.
Antibody Responsiveness to Influenza: What Drives It?
Pathogenesis of Avian Influenza Virus Subtype H9N2 in Turkeys and Evaluation of Inactivated Vaccine Efficacy
Molecular Characterization of Closely Related H6N2 Avian Influenza Viruses Isolated from Turkey, Egypt, and Uganda
Antigenic and molecular characterization of low pathogenic avian influenza A(H9N2) viruses in sub-Saharan Africa from 2017 through 2019
Emerging Influenza D virus infection in European livestock as determined in serology studies: Are we underestimating its spread over the continent?
Formal estimation of the seropositivity cut-off of the hemagglutination inhibition assay in field diagnosis of influenza D virus in cattle and estimation of the associated true prevalence in Morocco
From one to many: The within-host rise of viral variants.
Intranasal type I interferon treatment is beneficial only when administered before clinical signs onset in the SARS- CoV-2 hamster model.
Vaccination of Sheep with Bovine Viral Diarrhea Vaccines Does Not Protect against Fetal Infection after Challenge of Pregnant Ewes with Border Disease Virus
Household Cases Suggest That Cats Belonging to Owners with COVID-19 Have a Limited Role in Virus Transmission.
Detection and Typing of a Fowl Adenovirus Type 1 Agent of Pancreatitis in Guinea Fowl
Viral tropism and detection of clade 2.3.4.4b H5N8 highly pathogenic avian influenza viruses in feathers of ducks and geese.